CENO: A Genome-Scale World Model for Evolutionary Sequence Interpretation and Programmable Regulatory Design

CENO is a family of long-context generative genomic world models that uses one autoregressive backbone to understand long DNA, score mutation effects with evolutionary context, and design regulatory sequences. Its staged curriculum reaches one-million-token whole-genome context, while evolutionary post-training and reinforcement-learning-guided design connect sequence interpretation with programmable biological function.